Isoi was founded after its founder, Jinmin Lee, had struggled with severe acne for many years and tried countless products from different brands in search of a solution. Instead of improving, his skin condition worsened, and the side effects of medical treatments left his skin extremely sensitive. After reading a European report suggesting that synthetically derived ingredients produced through chemical processes are likely to interfere with the skin's natural functions, while products made exclusively with natural ingredients may help improve skin concerns, Jinmin began searching for a natural skincare brand that could help his skin. Having spent several years as the head of the cosmetics company Logona, Jinmin came to realize that the key to effective skincare products was not the combination of natural ingredients themselves, but the technology used to bring those ingredients together. This realization became the foundation of Isoi.